AstraZeneca/Oxford say Covid vaccine shows 70% efficacy, can be 90% effective
"This vaccine's efficacy and safety confirm that it will be highly effective against Covid-19 and will have an immediate impact on this public health emergency," AstraZeneca chief executive Pascal Soriot said in a statement.
One dosing regimen shows vaccine efficacy of 90% when AZD1222 was given as half dose, followed by full dose at least a month apart. Second dosing regimen shows 62% efficacy when given two full doses at least a month apart. Combined analysis has average efficacy of 70%, said AstraZeneca
No serious safety events related to the vaccine have been confirmed and it was well tolerated across both dosing regimens, it said.
"This vaccine's efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency," Pascal Soriot, Astra's chief executive, said in a statement.
The Serum Institute of India has partnered with AstraZeneca to produce COVID-19 vaccine for global supply.
The British drugmaker's preliminary trial results mark a fresh breakthrough in the fight against a pandemic that has killed nearly 1.4 million people and roiled the global economy.
British Prime minister Boris Johnson said it was "incredibly exciting news the Oxford vaccine has proved so effective in trials."
AstraZeneca shares fell 1.1% in early morning trade, defying expectations for a bounce and underperforming the wider market with the FTSE 100 index rising 0.5% at the open.
The interim analysis was based on 131 infections among participants who received the vaccine and those in a control group who were given an established meningitis shot.
The data showing a range of efficacy between 60% and 90% comes after U.S. rivals published interim data in recent weeks showing efficacy of more than 90%.
While the efficacy reading from Astra's viral vector vaccine is lower than its U.S. rivals, the data will boost confidence about the chances of successfully developing a variety of vaccines using different approaches. Public health experts say the world will need many vaccines to meet global demand.
On Nov. 16, U.S.-based Moderna Inc said its experimental vaccine proved to be 94.5% effective based on an early data analysis.
A week earlier, Pfizer Inc and Germany's BioNTech SE said their vaccine candidate had demonstrated greater than 90% efficacy that rose to 95% with analysis of full trial data.
I am delighted to hear that, Covishield, a low-cost, logistically manageable & soon to be widely available,… https://t.co/Q576gRhwbL— Adar Poonawalla (@adarpoonawalla) 1606120250000
The AstraZeneca vaccine uses a modified version of a chimpanzee common cold virus to deliver instructions to cells to fight the target virus, which is different than the new technology known as messenger RNA (mRNA) deployed by Pfizer/BioNTech and Moderna.
The company - one of the UK's most valuable listed companies - will now immediately prepare regulatory submission of the data to authorities around the world that have a framework in place for conditional or early approval.
It will also seek an emergency use listing from the World Health Organization to speed up availability in low-income countries. In parallel, the full analysis of the interim results is being submitted for publication in a peer-reviewed journal.