Plasma therapy may be safe, effective for children with life-threatening Covid infection

The study involved four patients with acute respiratory distress syndrome.

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Convalescent plasma also did not suppress endogenous antibody response, the researchers said.
WASHINGTON: Convalescent plasma therapy appears to be a safe and possibly effective treatment for children with life-threatening cases of Covid-19, according to a small study.

The research, published in the journal Pediatric Blood and Cancer, is the first report of convalescent plasma in children with life-threatening Covid-19.

Researchers from Children's Hospital of Philadelphia (CHOP) in the US noted that no therapies have been yet proven safe and effective for children who develop life-threatening complications from contracting the SARS-COV-2 virus.


One possible treatment that has been explored in adults is the use of convalescent plasma, which is derived from patients who have recovered from COVID-19, they said.

The therapy can be administered in currently ill patients to generate an antibody response that renders the virus inert, according to the researchers.

Early positive results were observed in adults who received convalescent plasma, but the treatment had not been studied in children, they said.
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"Some children who contract this virus can develop very serious complications, so even with limited data in adults, we believed it was worth exploring the use of convalescent plasma as a possible treatment option," said David Teachey, senior author of the study, from CHOP.

The study involved four patients with acute respiratory distress syndrome.

The researchers measured donor antibody levels and recipient antibody response prior to and following the convalescent plasma infusion to determine whether there were any adverse reactions.

In the four patients that were studied, the use of convalescent plasma was not associated with antibody-dependent enhancement, in which antibodies developed during a previous infection cause a worsened response with subsequent infections, a concern that has been described in preclinical models of other coronaviruses.
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Convalescent plasma also did not suppress endogenous antibody response, the researchers said.

"We believe that convalescent plasma may provide the greatest benefit for patients who are early into their illness and have not yet generated endogenous antibodies," Teachey said.
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"While the small sample size of our study does not allow us to draw any definitive conclusions, we believe this method is safe and future research should include randomised controlled trials to more definitively examine how effective convalescent plasma may be in treating children infected with Covid-19," he added.

World Kidney Day: Drinking 8 Glasses Of Water Flushes Toxins And Other Myths About Renal Health
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Kidneys are one of the most vital organs in the body which excrete the toxic waste products formed as a result of metabolism in the body. Kidneys also maintain the fluids and salt balance of the body, and make hormones that help produce red blood cells, promote bone health and regulate blood pressure.



Chronic Kidney Disease is the most common kidney-related ailment, and involves the gradual irreversible loss of kidney function over a period of years.



Diabetes, and hypertension are major risk factors for chronic kidney disorder which is growing rapidly amongst Indians. Other risk factors for kidney diseases include obesity, family history of kidney disease, and excessive use of pain killers, active smoking, heart disease and older age.



On World Kidney Day, Dr Vijay Kher, Chairman, Kidney and Urology Institute of Medanta Hospital, Gurugram debunked the popular myths surrounding kidney disease and renal health, and shared better prevention and management tips of the condition.

Kidneys are one of the most vital organs in the body which excrete the toxic waste products formed as a result of metabolism in the body. Kidneys also maintain the fluids and salt balance of the body..
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FACT: Chronic kidney disease is usually a progressive disease. However, there are treatments that can help preserve or delay the deterioration of remaining kidney function. Incorporating healthy lifestyle changes can help improve the quality of life of patients. These include, but are not limited to, changes such as quitting smoking, consuming a well-balanced diet, engaging in regular physical activity and keeping ones blood pressure and diabetes under control.
FACT: Chronic kidney disease is usually a progressive disease. However, there are treatments that can help preserve or delay the deterioration of remaining kidney function. Incorporating healthy life..
Read More
FACT: Most of us are born with two normally functioning kidneys, but most people with one healthy kidney lead a normal life. In some cases, people may have one kidney on ground of donation or removal of one kidney due to cancer or severe infection with or without stones. A single healthy kidney can perform the essential functions of both.
FACT: Most of us are born with two normally functioning kidneys, but most people with one healthy kidney lead a normal life. In some cases, people may have one kidney on ground of donation or removal..
Read More
FACT: Common symptoms of kidney disease include swelling of the eyes and feet, frothy urine or blood in the urine. However, most kidney diseases do not show symptoms in the early stages. Thus, detecting kidney disease in early stages can only be done through screening individuals who are at high risk. These include people who are elderly and/or obese, and/or have a family history of diabetes, kidney disease or heart disease.
FACT: Common symptoms of kidney disease include swelling of the eyes and feet, frothy urine or blood in the urine. However, most kidney diseases do not show symptoms in the early stages. Thus, detect..
Read More
FACT: There is no medical evidence to support this statement. Drinking large amounts of water do not protect from kidney disease. Thirst controls the desire to drink water and should determine the amount of fluid intake. Patients who are undergoing treatment for kidney disease are often advised to drink less salt and fluids as fluid retention can cause shortness of breath, swollen ankles and increase in weight gain.
FACT: There is no medical evidence to support this statement. Drinking large amounts of water do not protect from kidney disease. Thirst controls the desire to drink water and should determine the am..
Read More
FACT: Chronic kidney disease is one of the leading causes of death, globally. According to the World Health Organization, the estimated prevalence of chronic kidney disease worldwide is 8-16 per cent in adults above 30 years of age. Stressful lifestyles and unhealthy eating habits contribute to increased incidence of diabetes, hypertension and obesity thus increasing the kidney disease risk.
FACT: Chronic kidney disease is one of the leading causes of death, globally. According to the World Health Organization, the estimated prevalence of chronic kidney disease worldwide is 8-16 per cent..
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FACT: Foods with high salt and high potassium need to be restricted in patients with moderately severe kidney disease. Protein malnutrition is common in patients and one of the reasons for poor outcome of chronic kidney diseases. 50 per cent of proteins must be consumed through milk and milk products and non-vegetarian foods (high quality proteins). Regular intake of green leafy vegetables, normal spices, low salt and low potassium is recommended.
FACT: Foods with high salt and high potassium need to be restricted in patients with moderately severe kidney disease. Protein malnutrition is common in patients and one of the reasons for poor outco..
Read More
FACT: Diabetes and hypertension are two common causes of kidney disease. If these are effectively controlled, then kidney disease can be prevented. Apart from this, timely screening and early detection can also play a significant role in prevention of kidney disease, especially the ones in advanced stages. If detected early, the need for dialysis or transplant can be omitted or delayed.
FACT: Diabetes and hypertension are two common causes of kidney disease. If these are effectively controlled, then kidney disease can be prevented. Apart from this, timely screening and early detecti..
Read More
FACT: Dialysis is a method of purification of blood of waste products which are not removed because of kidney failure. Dialysis in fact does not do anything for kidney disease. Dialysis is only required when kidney function decreases to less than 15 ml/min (stage V chronic kidney disease or kidney failure) and patients cannot sustain life meaningfully. In earlier stages of chronic kidney disease, one slows down the rate of progression of kidney disease to delay or avoid the need for dialysis or kidney transplantation.
FACT: Dialysis is a method of purification of blood of waste products which are not removed because of kidney failure. Dialysis in fact does not do anything for kidney disease. Dialysis is only requi..
Read More

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